genomic variant – Communicable Diseases Research

Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approach

Short communication

Published on 2022-12-012022-10-05
Journal: Biochemistry and Biophysics Reports
[Category] 신약개발,

Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] 바이오마커, 변종, 치료제,

[키워드] Accuracy applied approaches clinical sample clinician Complete COVID-19 pandemic Culture deaths described detect Diagnosis diagnostic test disease drug drug resistance drug susceptibility drugs effective Establishing evaluate evaluated faster genetic marker Genetic variant genetics genomic variant helping identification identify infecting Infectious disease information initial Initially molecular molecular test Mutation Mycobacterium Mycobacterium tuberculosis negatively affected Next-generation sequencing NGS phenotypic Phylogenetic phylogenetically Phylogeny protocol Rapid reducing reliability reported resistance responsible resulting Sample sequenced Sequencing sputum Sputum sample sputum samples Stage strain targeted sequencing TB patient the WHO Treatment Tuberculosis tuberculosis. was used WGS WHO
[DOI] 10.1128/spectrum.01252-22 PMC 바로가기

Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret Model

Article

Published on 2022-10-262022-11-15
Journal: mBio
[Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant Variant. variants virulence virus virus virus infection virus load WA1 while
[DOI] 10.1128/mbio.02421-22 PMC 바로가기

Early detection and surveillance of SARS-CoV-2 genomic variants in wastewater using COJAC

COJAC을 사용한 폐수 내 SARS-CoV-2 게놈 변이체의 조기 탐지 및 감시

Article

Published on 2022-08-012022-09-11
Journal: Nature Microbiology
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

A simple reverse genetics method to generate recombinant coronaviruses

재조합 코로나바이러스를 생성하는 간단한 역유전학 방법

Article

Published on 2022-05-042022-09-11
Journal: EMBO Reports
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance Antiviral assays antivirals biological property Biology cDNA Characteristics Complete coronavirus coronavirus coronavirus genome coronavirus genomes Diagnosis effective Engineering facilitate fluorescent generate genetics genomic genomic variant genomic variants in vivo in vivo experiment in vivo experiments molecular Mutation Pathogens reagents reconstruction reporter reporter strain reverse genetics SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants serological serology Serology. severe acute respiratory syndrome Coronavirus simplicity Specific specific mutations Strains the SARS-CoV-2 the SARS-CoV-2 genome therapeutic variants viral pathogen virus wild-type
[DOI] 10.15252/embr.202153820 PMC 바로가기 [Article Type] Article

Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic Variants

SARS-CoV-2에 대한 고전 및 차세대 백신 플랫폼: 생명공학 전략 및 게놈 변이

Review

Published on 2022-02-182022-09-10
Journal: International Journal of Environmental Research an
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘,

[키워드] aAPC Ad5-nCoV adaptive Amino acid amino acids animals antibody applied B.1.1.7 B1.351 BBIBP-CorV bind Biotechnology BNT Cell classical clinical trial consequence CoronaVac coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs D614G Deletion demonstrated dendritic cell dendritic cells domain escape Evolution genomic variant genomic variants HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high affinity HKU1 hosts Human humans inactivated incorporation inhibit INO-4800 JNJ-78436735 lentiviral Lentiviral vector LV-SMENP-DC MERS-CoV molecular mRNA mRNA-1273 mutated nCoV New new SARS-CoV-2 new strain NL63 NVX-CoV2373 vaccine P.1 pathogen Pathogens platform Protein RBD receptor ACE2 Receptor-binding domain recombinant vaccine recombinant vaccines replacement residue responsible RNA vaccines S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants strain Strains Strategy subunits technological platforms tested the S protein Transmissibility trials Vaccine vaccine production Vaccines variant variants variety Viral virus-like particles β-coronavirus β-CoV β-CoVs
[DOI] 10.3390/ijerph19042392 PMC 바로가기 [Article Type] Review

Importation, circulation, and emergence of variants of SARS-CoV-2 in the South Indian state of Karnataka

Research Article

Published on 2022-02-072022-10-28
Journal: Wellcome Open Research
[Category] COVID-19,

[키워드] acute respiratory syndrome amino acid changes amino acid replacement Analysis B.1 B.1.1.7 B.1.351 Brazil changes in circulating circulation coronavirus coronavirus disease COVID-19 COVID-19 India Critical distribution fraction Genomic epidemiology genomic variant Immune escape India International introduced Karnataka Lineage lineages Local MONITOR nine outbreak Outbreak investigation pandemic performed positive Re-infection reported SARS-CoV-2 SARS-CoV-2 spread SARS-CoV-2 variants of concern sequenced severe disease South South Africa south India Spread Support the study group Transmission Travel variant variants variants of concern variants of SARS-CoV-2 virus VoC whole genome
[DOI] 10.12688/wellcomeopenres.16768.2 PMC 바로가기 [Article Type] Research Article

SBSA: an online service for somatic binding sequence annotation

SBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스

Article

Published on 2022-01-112022-09-11
Journal: Nucleic Acids Research
[Category] 변종, 유전자 메커니즘,

Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia

콜롬비아에서 전염병이 발생한 첫해 샘플에서 SARS-CoV-2 게놈의 돌연변이 프로필

Article

Published on 2022-01-012022-09-11
Journal: Infection, genetics and evolution : journal of mol
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus base pairs Beta CDC circulating clade collected concern coronavirus correlation COVID-19 D614G diagnostic diagnostic test disease severity E484K Effectiveness Evidence followed by Gamma genetic change genetic information Genetic variation genomic genomic variant GISAID Health Organization High-throughput nucleotide sequencing host immunity interest L18F lAbel Lineage Missense MOST Mutation next generation sequencing NGS non-structural proteins nucleotide ORF1ab gene pandemic predominant recent regions S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants sequenced South America structural protein structural proteins Surveillance synonymous the SARS-CoV-2 genome the WHO Vaccines variants virus VoC WHO Whole genome sequencing whole genome sequencing. World Health Organization
[DOI] 10.1016/j.meegid.2021.105192 PMC 바로가기 [Article Type] Article

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

COVID-19 질병의 발병기전에서 ACE-2 수용체의 역할 이해: 치료적 개입을 위한 잠재적 접근

Review

Published on 2021-12-012022-09-11
Journal: Pharmacological Reports
[Category] SARS, 변종,

[키워드] ACE ACE gene ACE-2 receptor ACE2 ACE2 receptor ACE2 receptors acute lung injury acute respiratory distress syndrome aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach cardiovascular system Cell correlation COVID-19 COVID-19 pathogenesis disorders distress enzyme genomic variant homologue human cells hypertension intake lung Lung injury manifestation medications molecular pandemic of COVID-19 pathogenesis of COVID-19 pathophysiology pathway persistence Proteins question raised raising receptor Renin renin-angiotensin-aldosterone system researcher respiratory distress Respiratory distress syndrome rhACE2. SARS-CoV-2 SARS-CoV-2-infected patients therapeutic intervention these viruses understanding viral particle virus
[DOI] 10.1007/s43440-021-00303-6 PMC 바로가기 [Article Type] Review